top of page
EXPANDing the value of Extracellular Vesicles
as carriers of biomarker and therapy in precision healhcare
Introducing EXPAND-EV
Extracellular vesicles (EVs) play a key role in cellular communication, offering great potential for transforming healthcare. They provide valuable insights into disease states, enabling early detection, monitoring, and personalized treatments. EVs also show promise as drug delivery systems to improve patient outcomes. However, current technological limitations and the absence of standardized methodologies prevent their full clinical application.
Project Overview
The project will validate the EV purification system in clinical laboratories using samples from breast, liver, and lung cancer patients. By analyzing the proteomic, glycomic, and transcriptomic signatures of EVs, researchers will identify new biomarker panels. These biomarkers will facilitate early cancer detection, non-invasive prognosis, and the development of personalized therapeutic strategies.
EXPAND-EV is pioneering the use of edible plant-derived EVs (PDEVs) as natural carriers for therapeutic small interfering RNA (siRNA) molecules. The project will establish Good Manufacturing Practice (GMP)-compliant protocols to produce these PDEVs and evaluate their safety and efficacy in preclinical cancer models. This research has the potential to create a non-invasive, sustainable, and effective drug delivery platform.
Latest news
bottom of page